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dc.contributor.authorZmrhal, Vladimír
dc.contributor.authorSláma, Petr
dc.date.accessioned2022-04-19T00:02:20Z
dc.date.available2022-04-19T00:02:20Z
dc.date.issued2020
dc.identifier.issn2076-2615 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1550
dc.description.abstractAlthough the immunomodulatory properties of prebiotics were demonstrated many years ago in poultry, not all mechanisms of action are yet clear. Dendritic cells (DCs) are the main antigen-presenting cells orchestrating the immune response in the chicken gastrointestinal tract, and they are the first line of defense in the immune response. Despite the crucial role of DCs in prebiotic immunomodulatory properties, information is lacking about interaction between prebiotics and DCs in an avian model. Mannan-oligosaccharides, β-glucans, fructooligosaccharides, and chitosan-oligosaccharides are the main groups of prebiotics having immunomodulatory properties. Because pathogen-associated molecular patterns on these prebiotics are recognized by many receptors of DCs, prebiotics can mimic activation of DCs by pathogens. Short-chain fatty acids are products of prebiotic fermentation by microbiota, and their anti-inflammatory properties have also been demonstrated in DCs. This review summarizes current knowledge about avian DCs in the gastrointestinal tract, and for the first-time, their role in the immunomodulatory properties of prebiotics within an avian model.en
dc.format698
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofAnimals
dc.relation.urihttps://doi.org/10.3390/ani10040698
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectavian dendritic cellsen
dc.subjectprebioticen
dc.subjectpattern recognition receptorsen
dc.subjectantigen-presenting cellen
dc.subjectchickenen
dc.titleImmunomodulation of Avian Dendritic Cells under the Induction of Prebioticsen
dc.typeJ_ČLÁNEK
dc.date.updated2022-04-19T00:02:20Z
dc.description.versionOA
local.identifier.doi10.3390/ani10040698
local.identifier.scopus2-s2.0-85083766027
local.identifier.wos000531832800155
local.number4
local.volume10
local.identifier.obd43919183
local.identifier.e-issn2076-2615
dc.project.IDAF-IGA2020-IP040
dc.project.IDCharakteristika dendritických buněk v trávicím traktu brojlerových kuřat
dc.identifier.orcidZmrhal, Vladimír 0000-0003-4534-685X
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Zobrazit minimální záznam

CC BY 4.0
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