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dc.contributor.authorSvoradová, Andrea
dc.contributor.authorZmrhal, Vladimír
dc.contributor.authorVenusová, Eva
dc.contributor.authorSláma, Petr
dc.date.accessioned2022-08-17T00:02:19Z
dc.date.available2022-08-17T00:02:19Z
dc.date.issued2021
dc.identifier.issn2076-2615 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1612
dc.description.abstractMesenchymal stem cells (MSCs) are multipotent progenitor cells that adhere to plastic; express the specific markers CD29, CD44, CD73, CD90, and CD105; and produce cytokines and growth factors supporting and regulating hematopoiesis. MSCs have capacity for differentiating into osteocytes, chondrocytes, adipocytes, and myocytes. They are useful for research toward better understanding the pathogenic potential of the infectious bursal disease virus, mineralization during osteogenesis, and interactions between MSCs as a feeder layer to other cells. MSCs are also important for immunomodulatory cell therapy, can provide a suitable strategy model for coculture with pathogens causing dermatitis disorders in chickens, can be cultured in vitro with probiotics and prebiotics with a view to eliminate the feeding of antibiotic growth promoters, and offer cell-based meat production. Moreover, bone marrow-derived MSCs (BM-MSCs) in coculture with hematopoietic progenitor/stem cells (HPCs/HSCs) can support expansion and regulation of the hematopoiesis process using the 3D-culture system in future research in chickens. MSCs' several advantages, including ready availability, strong proliferation, and immune modulatory properties make them a suitable model in the field of stem cell research. This review summarizes current knowledge about the general characterization of MSCs and their application in chicken as a model organism.en
dc.format1883
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofAnimals
dc.relation.urihttps://doi.org/10.3390/ani11071883
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectchickenen
dc.subjectmesenchymal stem cellsen
dc.subjectcultureen
dc.subjectdiseaseen
dc.subjectprobioticsen
dc.subjectapplicationsen
dc.titleChicken Mesenchymal Stem Cells and Their Applications: A Mini Reviewen
dc.typeJ_ČLÁNEK
dc.date.updated2022-08-17T00:02:19Z
dc.description.versionOA
local.identifier.doi10.3390/ani11071883
local.identifier.scopus2-s2.0-85108431573
local.identifier.wos000686147500001
local.number7
local.volume11
local.identifier.obd43921391
local.identifier.e-issn2076-2615
dc.project.IDTJ04000511
dc.project.IDInovativní přístupy k eliminaci negativního vlivu skladování násadových vajec na líhnutí kuřat a jejich parametry užitkovosti
dc.identifier.orcidSvoradová, Andrea 0000-0003-4626-4450
dc.identifier.orcidZmrhal, Vladimír 0000-0003-4534-685X
dc.identifier.orcidVenusová, Eva 0000-0003-1782-6338
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Zobrazit minimální záznam

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