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dc.contributor.authorSteinerová, Michala
dc.contributor.authorHorecký, Čeněk
dc.contributor.authorHorecká, Eliška
dc.contributor.authorKnoll, Aleš
dc.contributor.authorNedomová, Šárka
dc.contributor.authorSláma, Petr
dc.contributor.authorPavlík, Aleš
dc.date.accessioned2023-04-15T00:03:02Z
dc.date.available2023-04-15T00:03:02Z
dc.date.issued2022
dc.identifier.issn1319-562X Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1675
dc.description.abstractThe Wnt signaling pathway plays a critical role in almost all aspects of skeletal development and homeostasis. Many studies suggest the importance of this signaling pathway in connection with bone metabolism through many skeletal disorders caused by mutations in Wnt signaling genes. The knowledge gained through targeting this pathway is of great value for skeletal health and diseases, for example of increased bone mass in the case of osteoporosis. Our objective was to focus on the detection of single nucleotide polymorphisms and investigate the associations between possible polymorphisms in selected genes that are part of those signaling pathways and parameters of bones in hens of ISA Brown hybrids (bone breaking strength, length, width, and bone mass). Different regions of the GPR177, ESR1 and RUNX2 genes were studied, using PCR and sequencing, in a total of forty-eight samples for each marker. Thirteen polymorphisms have been discovered in selected regions of studied genes, whereas these polymorphisms were only within the GPR177 gene. Eight of these polymorphisms were synonymous and five were in the intron. The tested regions of the ESR1 and RUNX2 genes were monomorphic. The only statistically significant difference was found within the GPR177 gene (exon 2) and the bone length parameter, in the c.443 + 86G>A polymorphism. However, this polymorphism was found in the intron, and no other one was found within the selected regions to show associations with the observed bone parameters.en
dc.format2526-2531
dc.publisherElsevier Science BV
dc.relation.ispartofSaudi Journal of Biological Sciences
dc.relation.urihttps://doi.org/10.1016/j.sjbs.2021.12.024
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectWnt signaling pathwayen
dc.subjectpolymorphismen
dc.subjectboneen
dc.subjectosteoporosisen
dc.subjectlaying hensen
dc.titleStudy of selected genes of Wnt signaling pathway in relation to the parameters in the bone tissue of the laying hensen
dc.typeJ_ČLÁNEK
dc.date.updated2023-04-15T00:03:02Z
dc.description.versionOA
local.identifier.doi10.1016/j.sjbs.2021.12.024
local.identifier.scopus2-s2.0-85122297282
local.identifier.wos000798983400064
local.number4
local.volume29
local.identifier.obd43922295
local.identifier.e-issn2213-7106
dc.project.IDAF-IGA2020-IP053
dc.project.IDStudium jednonukleotidových polymorfismů vybraných genů a kvantifikace buněčných proteinů kostní tkáně nosnic
dc.identifier.orcidSteinerová, Michala 0000-0003-4165-9453
dc.identifier.orcidKnoll, Aleš 0000-0002-4230-8535
dc.identifier.orcidNedomová, Šárka 0000-0001-8840-7849
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
dc.identifier.orcidPavlík, Aleš 0000-0003-1004-4835
local.contributor.affiliationAF


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CC BY-NC-ND 4.0
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