Zobrazit minimální záznam

dc.contributor.authorKomprda, Tomáš
dc.contributor.authorSládek, Zbyšek
dc.contributor.authorVícenová, Monika
dc.contributor.authorSimonová, Jana
dc.contributor.authorFranke, Gabriela
dc.contributor.authorLipový, Břetislav
dc.contributor.authorMatejovičová, Milena
dc.contributor.authorKacvinská, Katarína
dc.contributor.authorSabliov, Cristina
dc.contributor.authorAstete, Carlos E.
dc.contributor.authorLevá, Lenka
dc.contributor.authorPopelková, Vendula
dc.contributor.authorBátik, Andrej
dc.contributor.authorVojtová, Lucy
dc.date.accessioned2023-01-21T01:02:37Z
dc.date.available2023-01-21T01:02:37Z
dc.date.issued2022
dc.identifier.issn1661-6596 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1638
dc.description.abstractThe utilization of poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) loaded in collagen-based scaffolds for cutaneous wound healing using a porcine model is unique for the present study. Full-depth cutaneous excisions (5 x 5 cm) on the pig dorsa were treated with pure collagen scaffold (control, C), empty PLGA NPs (NP), FO, mupirocin (MUP), PLGA NPs with entrapped FO (NP/FO) and PLGA NPs with entrapped MUP (NP/MUP). The following markers were evaluated on days 0, 3, 7, 14 and 21 post-excision: collagen, hydroxyproline (HP), angiogenesis and expressions of the COX2, EGF, COL1A1, COL1A3, TGFB1, VEGFA, CCL5 and CCR5 genes. The hypothesis that NP/FO treatment is superior to FO alone and that it is comparable to NP/MUP was tested. NP/FO treatment increased HP in comparison with both FO alone and NP/MUP (day 14) but decreased (p < 0.05) angiogenesis in comparison with FO alone (day 3). NP/FO increased (p < 0.05) the expression of the CCR5 gene (day 3) and tended (p > 0.05) to increase the expressions of the EGF (day 7, day 14), TGFB1 (day 21) and CCL5 (day 7, day 21) genes as compared with NP/MUP. NP/FO can be suggested as a suitable alternative to NP/MUP in cutaneous wound treatment.en
dc.format7663
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.urihttps://doi.org/10.3390/ijms23147663
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcutaneous woundsen
dc.subjectpolyunsaturated fatty acids n-3en
dc.subjectnanoparticlesen
dc.subjectpoly(lactic-co-glycolic) aciden
dc.subjectmupirocinen
dc.subjectcollagenen
dc.subjecthydroxyprolineen
dc.subjectcyclooxygenase-2en
dc.subjecttransforming growth factoren
dc.titleEffect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Modelen
dc.typeJ_ČLÁNEK
dc.date.updated2023-01-21T01:02:37Z
dc.description.versionOA
local.identifier.doi10.3390/ijms23147663
local.identifier.scopus2-s2.0-85135120908
local.identifier.wos000832282300001
local.number14
local.volume23
local.identifier.obd43923149
local.identifier.e-issn1422-0067
dc.project.IDAF-IGA2019-TP006
dc.project.IDVliv kombinace polynenasycených mastných kyselin n-3 a nanočástic na hojení kožních ran u modelového organizmu
dc.identifier.orcidKomprda, Tomáš 0000-0002-2547-2368
dc.identifier.orcidSládek, Zbyšek 0000-0002-9268-4811
dc.identifier.orcidSimonová, Jana 0000-0003-1901-3496
dc.identifier.orcidFranke, Gabriela 0000-0001-9812-4471
dc.identifier.orcidMatejovičová, Milena 0000-0001-6878-7426
dc.identifier.orcidPopelková, Vendula 0000-0001-9992-5684
dc.identifier.orcidBátik, Andrej 0000-0001-9630-4356
local.contributor.affiliationAF


Soubory tohoto záznamu

Thumbnail

Tento záznam se objevuje v následujících kolekcích

Zobrazit minimální záznam

CC BY 4.0
Kromě případů, kde je uvedeno jinak, licence tohoto záznamu je CC BY 4.0