Zobrazit minimální záznam

dc.contributor.authorZušťáková, Martina
dc.contributor.authorKratochvílová, Lucie
dc.contributor.authorSláma, Petr
dc.date.accessioned2022-04-23T00:02:19Z
dc.date.available2022-04-23T00:02:19Z
dc.date.issued2020
dc.identifier.issn2079-7737 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1559
dc.description.abstractIn the past 10 years, the number of people in the Czech Republic with allergies has doubled to over three million. Allergic pollen catarrh, constitutional dermatitis and asthma are the allergic disorders most often diagnosed. Genuine food allergies today affect 6-8% of nursing infants, 3-5% of small children, and 2-4% of adults. These disorders are connected with eosinophil granulocytes and their apoptosis. Eosinophil granulocytes are postmitotic leukocytes containing a number of histotoxic substances that contribute to the initiation and continuation of allergic inflammatory reactions. Eosinophilia results from the disruption of the standard half-life of eosinophils by the expression of mechanisms that block the apoptosis of eosinophils, leading to the development of chronic inflammation. Glucocorticoids are used as a strong acting anti-inflammatory medicine in the treatment of hypereosinophilia. The removal of eosinophils by the mechanism of apoptosis is the effect of this process. This work sums up the contemporary knowledge concerning the apoptosis of eosinophils, its role in the aforementioned disorders, and the indications for the use of glucocorticoids in their related therapies.en
dc.format457
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofBiology
dc.relation.urihttps://doi.org/10.3390/biology9120457
dc.relation.urihttps://www.mdpi.com/2079-7737/9/12/457
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectapoptosisen
dc.subjectinflammationen
dc.subjectallergyen
dc.subjecteosinophil granulocyteen
dc.titleApoptosis of Eosinophil Granulocytesen
dc.typeJ_ČLÁNEK
dc.date.updated2022-04-23T00:02:19Z
dc.description.versionOA
local.identifier.doi10.3390/biology9120457
local.identifier.scopus2-s2.0-85099298362
local.identifier.wos000601877800001
local.number12
local.volume9
local.identifier.obd43920216
local.identifier.e-issn2079-7737
dc.project.IDAF-IGA-2018-tym002
dc.project.IDVliv bakterií a komponent jejich buněčných stěn na apoptózu leukocytů
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Zobrazit minimální záznam

CC BY 4.0
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