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dc.contributor.authorSkaličková, Sylvie
dc.contributor.authorAulichová, Tereza
dc.contributor.authorVenusová, Eva
dc.contributor.authorSkládanka, Jiří
dc.contributor.authorHorký, Pavel
dc.date.accessioned2022-04-21T00:02:16Z
dc.date.available2022-04-21T00:02:16Z
dc.date.issued2020
dc.identifier.issn1661-6596 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1556
dc.description.abstractIt is generally believed that antibacterial essential oils have the potential to become one of the alternatives in preventing diarrheal diseases of monogastric animals. The disadvantage is their low efficiency per oral due to easy degradation during digestion in the stomach. This study compares the efficacy of chitosan, alginate-chitosan, guar gum-chitosan, xanthan gum-chitosan and pectin-chitosan nanocapsules to the synthesis of pH-responsive biopolymeric nanocapsule for Thymus vulgaris, Rosmarinus officinalis and Syzygium aromaticum essential oils. Using spectrophotometric approach and gas chromatography, release kinetics were determined in pH 3, 5.6 and 7.4. The growth rates of S. aureus and E. coli, as well as minimal inhibition concentration of essential oils were studied. The average encapsulation efficiency was 60%, and the loading efficiency was 70%. The size of the nanocapsules ranged from 100 nm to 500 nm. Results showed that chitosan-guar gum and chitosan-pectin nanocapsules released 30% of essential oils (EOs) at pH 3 and 80% at pH 7.4 during 3 h. Similar release kinetics were confirmed for thymol, eugenol and α-pinene. Minimal inhibition concentrations of Thymus vulgaris and Syzygium aromaticum essential oils ranged from 0.025 to 0.5%. Findings of this study suggest that the suitable pH-responsive nanocapsule for release, low toxicity and antibacterial activity is based on chitosan-guar gum structure.en
dc.format1799
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.urihttps://doi.org/10.3390/ijms21051799
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectalginateen
dc.subjectchitosanen
dc.subjectE. colien
dc.subjectguar gumen
dc.subjectgastro-intestinal tracten
dc.subjectpectinen
dc.subjectRosmarinus officinalisen
dc.subjectS. aureusen
dc.subjectS. cerevisiaeen
dc.subjectSyzygium aromaticumen
dc.subjectThymus vulgarisen
dc.subjectxanthan gumen
dc.titleDevelopment of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oilsen
dc.typeJ_ČLÁNEK
dc.date.updated2022-04-21T00:02:16Z
dc.description.versionOA
local.identifier.doi10.3390/ijms21051799
local.identifier.scopus2-s2.0-85081013954
local.identifier.wos000524908500250
local.number5
local.volume21
local.identifier.obd43919032
local.identifier.e-issn1422-0067
dc.project.IDTJ02000325
dc.project.IDNanotransportéry monoglyceridů pro podporu diverzity střevního mikrobiomu drůbež
dc.identifier.orcidSkaličková, Sylvie 0000-0002-2808-001X
dc.identifier.orcidAulichová, Tereza 0000-0002-9965-6020
dc.identifier.orcidVenusová, Eva 0000-0003-1782-6338
dc.identifier.orcidSkládanka, Jiří 0000-0002-7179-7606
dc.identifier.orcidHorký, Pavel 0000-0001-6074-785X
local.contributor.affiliationAF


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CC BY 4.0
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