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dc.contributor.authorKomprda, Tomáš
dc.date.accessioned2021-06-28T00:02:17Z
dc.date.available2021-06-28T00:02:17Z
dc.date.issued2018
dc.identifier43916512
dc.identifier.issn0001-7213 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1363
dc.description.abstractThe present review summarizes results of experiments, mostly performed on rodents, regarding the effects of fish oil (FO) and its biologically active constituents, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the healing of cutaneous wounds, but also of selected other types of injury. Structure, metabolism and functions of EPA/DHA in an organism are briefly mentioned, with an emphasis on the ability of these long-chain polyunsaturated fatty acids to modulate inflammation. Wound healing as a complex programmed sequence of cellular and molecular processes including inflammation, cell migration, angiogenesis, synthesis of provisional matrix, collagen deposition and reepithelialisation is briefly described. Markers for evaluation of the healing process include planimetry indices, tensile strength, quantification of collagen synthesis including hydroxyproline determination, histopathology/immunohistochemistry and genomic/proteomic markers. As far as effects on wound healing are concerned, the main emphasis is put on the outcomes of experiments using a dietary FO/DHA/EPA administration, but the results of experiments with a parenteral application are also mentioned, together with selected relevant in vitro studies. An important conclusion from the above-mentioned studies is an inconsistency of FO/DHA/EPA effects on wound healing: decreased/increased collagen deposition; lower/higher counts of the inflammatory cells in the healing tissue; increased/decreased concentration of both pro- and anti-inflammatory cytokines; DHA accelerated/delayed wound healing process. Some experiments indicate superiority of DHA over EPA regarding wound healing.en
dc.format309-320
dc.publisherVeterinární a farmaceutická univerzita Brno
dc.relation.ispartofActa Veterinaria Brno
dc.relation.urihttps://doi.org/10.2754/avb201887040309
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHydroxyprolineen
dc.subjectinflammationen
dc.subjectinterleukinsen
dc.subjectrodentsen
dc.subjectdocosahexaenoic aciden
dc.subjectfish oilen
dc.titleEffect of n-3 long-chain polyunsaturated fatty acids on wound healing using animal models - a reviewen
dc.typeJ_ČLÁNEK
dc.date.updated2021-06-28T00:02:17Z
dc.description.versionOA
local.identifier.doi10.2754/avb201887040309
local.identifier.scopus2-s2.0-85060864050
local.identifier.wos000456052900001
local.number4
local.volume87
local.identifier.obd43916512
local.identifier.e-issn1801-7576
dc.project.IDAF - IGA - 2017 - tym004
dc.project.IDVýzkum vlivu dietární intervence s využitím olejů s vysokým obsahem eikosapentaénové a dokosahexaénové kyseliny na proces hojení ran
dc.identifier.orcidKomprda, Tomáš 0000-0002-2547-2368
local.contributor.affiliationAF


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Zobrazit minimální záznam

CC BY 4.0
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