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dc.contributor.authorRyskova, Lenka
dc.contributor.authorZahradnicek, Jan
dc.contributor.authorKukla, Rudolf
dc.contributor.authorBolehovska, Radka
dc.contributor.authorVajda, Milan
dc.contributor.authorPavlík, Ivo
dc.contributor.authorBostik, Pavel
dc.contributor.authorRyska, Pavel
dc.date.accessioned2023-09-19T00:03:21Z
dc.date.available2023-09-19T00:03:21Z
dc.date.issued2022
dc.identifier.issn2079-6382 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1780
dc.description.abstractInfections caused by Mycobacterium setense or Clostridium celerecrescens are extremely rare. In this report, for the first time a dual infection with these two pathogens is described. An 18-year-old female suffered multiple injuries, including an open comminuted fracture of the right humeral diaphysis after falling from a fifth-floor balcony in January 2019. Five months after the accident, a fistula appeared in the scar, reaching the bone tissue. M. setense and C. celerecrescens were cultured from sinus swabs and subsequently from perioperative samples. The patient was initially treated with a combination of intravenous antibiotics (ATBs): imipenem, amikacin, and ciprofloxacin. One month after the fracture fixation with a titanium nail, C. celerecrescens was again detected; therefore, metronidazole was added to the therapy. A triple combination of oral (PO) ATBs (trimethoprim-sulfamethoxazole, moxifloxacin, and metronidazole) followed, 8 weeks after the initial intravenous therapy. C. celerecrescens was cultured again two times, most recently in November 2019, when surgical debridement was supplemented by the topical administration of cancellous bone impregnated with vancomycin. Signs of bone healing were found at follow-ups and ATB treatment was finished in March 2020 after a total of 9 months of therapy. To this day, there have been no signs of reinfection. This case thus illustrates the need for a combination of systemic and individualized local therapy in the treatment of complicated cases of dual infections with rare pathogens.en
dc.format1254
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofAntibiotics
dc.relation.urihttps://doi.org/10.3390/antibiotics11091254
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectnontuberculous mycobacteriaen
dc.subjectrapidly growing mycobacteriaen
dc.subjectpost-traumatic osteomyelitisen
dc.subjectfracture-related infectionen
dc.titleDual Infection of an Open Fracture Caused by Mycobacterium setense and Clostridium celerecrescensen
dc.typeJ_ČLÁNEK
dc.date.updated2023-09-19T00:03:21Z
dc.description.versionOA
local.identifier.doi10.3390/antibiotics11091254
local.identifier.scopus2-s2.0-85138552304
local.identifier.wos000857441200001
local.number9
local.volume11
local.identifier.obd43923436
local.identifier.e-issn2079-6382
dc.project.IDNU20-09-00114
dc.project.IDNetuberkulózní mykobakterie v České Republice: současná rizika a zdokonalená prevence
dc.identifier.orcidPavlík, Ivo 0000-0002-5771-3381
local.contributor.affiliationFRRMS


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CC BY 4.0
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