Zobrazit minimální záznam

dc.contributor.authorDutta, Sulagna
dc.contributor.authorSengupta, Pallav
dc.contributor.authorDas, Sanghamitra
dc.contributor.authorSláma, Petr
dc.contributor.authorRoychoudhury, Shubhadeep
dc.date.accessioned2023-08-31T00:04:29Z
dc.date.available2023-08-31T00:04:29Z
dc.date.issued2022
dc.identifier.issn1661-6596 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1765
dc.description.abstractReactive nitrogen species (RNS), like reactive oxygen species (ROS), are useful for sustaining reproductive processes such as cell signaling, the regulation of hormonal biosynthesis, sperm capacitation, hyperactivation, and acrosome reaction. However, endogenous levels of RNS beyond physiological limits can impair fertility by disrupting testicular functions, reducing gonadotropin production, and compromising semen quality. Excessive RNS levels cause a variety of abnormalities in germ cells and gametes, particularly in the membranes and deoxyribonucleic acid (DNA), and severely impair the maturation and fertilization processes. Cell fragmentation and developmental blockage, usually at the two-cell stage, are also connected with imbalanced redox status of the embryo during its early developmental stage. Since high RNS levels are closely linked to male infertility and conventional semen analyses are not reliable predictors of the assisted reproductive technology (ART) outcomes for such infertility cases, it is critical to develop novel ways of assessing and treating oxidative and/or nitrosative stress-mediated male infertility. This review aims to explicate the physiological and pathological roles of RNS and their relationship with male reproduction.en
dc.format10574
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.urihttps://doi.org/10.3390/ijms231810574
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmale infertilityen
dc.subjectoxidative stressen
dc.subjectreactive nitrogen speciesen
dc.subjectreactive oxygen speciesen
dc.subjectsperm DNA fragmentationen
dc.titleReactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspectsen
dc.typeJ_ČLÁNEK
dc.date.updated2023-08-31T00:04:29Z
dc.description.versionOA
local.identifier.doi10.3390/ijms231810574
local.identifier.scopus2-s2.0-85138437093
local.identifier.wos000860787800001
local.number18
local.volume23
local.identifier.obd43923423
local.identifier.e-issn1422-0067
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Zobrazit minimální záznam

CC BY 4.0
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