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dc.contributor.authorDutta, Sulagna
dc.contributor.authorSengupta, Pallav
dc.contributor.authorBagchi, Sovan
dc.contributor.authorChhikara, Bhupender S.
dc.contributor.authorPavlík, Aleš
dc.contributor.authorSláma, Petr
dc.contributor.authorRoychoudhury, Shubhadeep
dc.date.accessioned2023-08-10T00:03:17Z
dc.date.available2023-08-10T00:03:17Z
dc.date.issued2023
dc.identifier.issn2296-634X Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1748
dc.description.abstractConfluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. It has been demonstrated in experimental investigations that a wide range of endocrine disrupting chemicals have negative effects on human reproductive function. However, evidence on the reproductive consequences of human exposure to endocrine disrupting chemicals is sparse and/or conflicting in the scientific literature. The combined toxicological assessment is a practical method for assessing the hazards of cocktails of chemicals, co-existing in the environment. The current review provides a comprehensive overview of studies emphasizing the combined toxicity of endocrine disrupting chemicals on human reproduction. Endocrine disrupting chemicals interact with each other to disrupt the different endocrine axes, resulting in severe gonadal dysfunctions. Transgenerational epigenetic effects have also been induced in germ cells, mostly through DNA methylation and epimutations. Similarly, after acute or chronic exposure to endocrine disrupting chemicals combinations, increased oxidative stress (OS), elevated antioxidant enzymatic activity, disrupted reproductive cycle, and reduced steroidogenesis are often reported consequences. The article also discusses the concentration addition (CA) and independent action (IA) prediction models, which reveal the importance of various synergistic actions of endocrine disrupting chemicals mixtures. More crucially, this evidence-based study addresses the research limitations and information gaps, as well as particularly presents the future research views on combined endocrine disrupting chemicals toxicity on human reproduction.en
dc.format1162015
dc.publisherFrontiers Media SA
dc.relation.ispartofFrontiers in Cell and Developmental Biology
dc.relation.urihttps://doi.org/10.3389/fcell.2023.1162015
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectendocrine disrupting chemicalsen
dc.subjectmetalsen
dc.subjecthuman fertilityen
dc.subjectinfertilityen
dc.subjectoxidative stressen
dc.subjectreductive stressen
dc.titleReproductive toxicity of combined effects of endocrine disruptors on human reproductionen
dc.typeJ_ČLÁNEK
dc.date.updated2023-08-10T00:03:16Z
dc.description.versionOA
local.identifier.doi10.3389/fcell.2023.1162015
local.identifier.scopus2-s2.0-85160245277
local.identifier.wos000995322700001
local.number12 May
local.volume11
local.identifier.obd43924949
local.identifier.e-issn2296-634X
dc.identifier.orcidPavlík, Aleš 0000-0003-1004-4835
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Zobrazit minimální záznam

CC BY 4.0
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