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dc.contributor.authorSochorová, Lenka
dc.contributor.authorBaroň, Mojmír
dc.contributor.authorDadakova, Katerina
dc.contributor.authorKasparovsky, Tomas
dc.contributor.authorSochor, Jiří
dc.date.accessioned2023-03-25T01:03:02Z
dc.date.available2023-03-25T01:03:02Z
dc.date.issued2021
dc.identifier.issn1420-3049 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1669
dc.description.abstractCadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.en
dc.format2099
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofMolecules
dc.relation.urihttps://doi.org/10.3390/molecules26072099
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectgrape seed extracten
dc.subjectantioxidantsen
dc.subjectcadmiumen
dc.subjectrattus norvegicusen
dc.subjectbiochemical markersen
dc.subjectprotective effecten
dc.titleHealth Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicusen
dc.typeJ_ČLÁNEK
dc.date.updated2023-03-25T01:03:02Z
dc.description.versionOA
local.identifier.doi10.3390/molecules26072099
local.identifier.scopus2-s2.0-85105184473
local.identifier.wos000638729000001
local.number7
local.volume26
local.identifier.obd43921187
local.identifier.e-issn1420-3049
dc.project.IDIGA - ZF/2016 - AP011
dc.project.IDEF16_017/0002334
dc.project.IDTrendy v zahradnictví a zahradní a krajinářské architektuře 2016
dc.project.IDVýzkumná infrastruktura pro mladé vědce
dc.identifier.orcidSochorová, Lenka 0000-0003-0378-5280
dc.identifier.orcidBaroň, Mojmír 0000-0003-1649-0537
dc.identifier.orcidSochor, Jiří 0000-0001-7823-1544
local.contributor.affiliationZF


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Except where otherwise noted, this item's license is described as CC BY 4.0