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dc.contributor.authorLeisegang, Kristian
dc.contributor.authorRoychoudhury, Shubhadeep
dc.contributor.authorSláma, Petr
dc.contributor.authorFinelli, Renata
dc.date.accessioned2022-08-17T00:02:16Z
dc.date.available2022-08-17T00:02:16Z
dc.date.issued2021
dc.identifier.issn2076-3921 Sherpa/RoMEO, JCR
dc.identifier.urihttps://repozitar.mendelu.cz/xmlui/handle/20.500.12698/1610
dc.description.abstractAndrogens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male repro- ductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is com- monly seen in ageing males, and has a complex relationship as a risk factor and a comorbidity in age-related noncommunicable chronic diseases (NCDs), such as obesity, metabolic syndrome, type 2 diabetes, and malignancy. Oxidative stress, as a significant contributor to the ageing process, is a common feature between ageing and NCDs, and the related comorbidities, including hypertension, dyslipidemia, hyperglycemia, hyperinsulinemia, and chronic inflammation. Oxidative stress may also be a mediator of hypogonadism in males. Consequently, the management of oxidative stress may represent a novel therapeutic approach in this context. Therefore, this narrative review aims to discuss the mechanisms of age-related oxidative stress in male hypogonadism associated with NCDs and discusses current and potential approaches for the clinical management of these patients, which may include conventional hormone replacement therapy, nutrition and lifestyle changes, ad-herence to the optimal body mass index, and dietary antioxidant supplementation and/or phyto-medicines.en
dc.format1834
dc.publisherMDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
dc.relation.ispartofAntioxidants
dc.relation.urihttps://doi.org/10.3390/antiox10111834
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantioxidantsen
dc.subjectnoncommunicable chronic diseaseen
dc.subjectnutritionen
dc.subjectphytonutrientsen
dc.subjecttestosteroneen
dc.subjecttestosterone replacement therapyen
dc.titleThe Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Diseaseen
dc.typeJ_ČLÁNEK
dc.date.updated2022-08-17T00:02:16Z
dc.description.versionOA
local.identifier.doi10.3390/antiox10111834
local.identifier.scopus2-s2.0-85119202126
local.identifier.wos000727286000001
local.number11
local.volume10
local.identifier.obd43921954
local.identifier.e-issn2076-3921
dc.identifier.orcidSláma, Petr 0000-0003-0570-259X
local.contributor.affiliationAF


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Except where otherwise noted, this item's license is described as CC BY 4.0