Browsing by Author "Sivák, Ladislav"

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Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules

Charousová, Markéta; Kudlickova Peskova, Marie; Takácsová, Paulína; Kapołková, Kateřina; Haddad, Yazan Abdulmajeed Eyadh; Bílek, Jan; Sivák, Ladislav; Bartejs, Tomas; Heger, Zbyněk; Pekařík, Vladimír (Royal Society of Chemistry, 2024)

Ferritins are globular proteins with an internal cavity that enables the encapsulation of a plethora of low-mass compounds. Unfortunately, the overall negative surface charge of ferritin's internal cavity hampers efficient ...
Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells

Merlos Rodrigo, Miguel Ángel; Michálková, Hana; Jiménez Jiménez, Ana María; Petrlák, František; Do, Tomáš; Sivák, Ladislav; Haddad, Yazan Abdulmajeed Eyadh; Kubíčková, Petra; de los Rios, Vivian; Casal, J. Ignacio; Serrano-Macia, Marina; Delgado, Teresa C.; Boix, Loreto; Bruix, Jordi; Chantar, Maria L. Martinez; Adam, Vojtěch; Heger, Zbyněk (BioMed Central Ltd., 2024)

Background & aims Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular ...