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Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules

Charousová, Markéta; Kudlickova Peskova, Marie; Takácsová, Paulína; Kapołková, Kateřina; Haddad, Yazan Abdulmajeed Eyadh; Bílek, Jan; Sivák, Ladislav; Bartejs, Tomas; Heger, Zbyněk; Pekařík, Vladimír (Royal Society of Chemistry, 2024)

Ferritins are globular proteins with an internal cavity that enables the encapsulation of a plethora of low-mass compounds. Unfortunately, the overall negative surface charge of ferritin's internal cavity hampers efficient ...