Browsing by Author "Pekařík, Vladimír"

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Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules

Charousová, Markéta; Kudlickova Peskova, Marie; Takácsová, Paulína; Kapołková, Kateřina; Haddad, Yazan Abdulmajeed Eyadh; Bílek, Jan; Sivák, Ladislav; Bartejs, Tomas; Heger, Zbyněk; Pekařík, Vladimír (Royal Society of Chemistry, 2024)

Ferritins are globular proteins with an internal cavity that enables the encapsulation of a plethora of low-mass compounds. Unfortunately, the overall negative surface charge of ferritin's internal cavity hampers efficient ...
Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

Vojníková, Michaela; Súkupová, Martina; Štefánik, Michal; Strakova, Petra; Haviernik, Jan; Kapołková, Kateřina; Gruberová, Eliška; Raskova, Klara; Michálková, Hana; Švec, Pavel; Kudličková Pešková, Marie; Huvarova, Ivana; Ruzek, Daniel; Salat, Jiri; Pekařík, Vladimír; Eyer, Ludek; Heger, Zbyněk (Dove Medical Press Ltd., 2024)

Background: As highlighted by recent pandemic outbreaks, antiviral drugs are crucial resources in the global battle against viral diseases. Unfortunately, most antiviral drugs are characterized by a plethora of side effects ...